Regulation of neural stem cells and brain development in health and diseases, including autism and fragile X syndrome.
- Study functions of RNA and RNA binding proteins in health and brain disorders, including autism, fragile X syndrome, and schizophrenia.
- Investigate epigenetic regulations and gene and environmental interactions in stem cells and development using gene editing, mouse genetics and human iPSCs
- Cell type specific and single cell analyses of neural stem cells and neurons using genomics, transcriptomics, and proteomics.
- Determine how gene mutations leads to neuronal and behavioral changes in mouse models for human diseases.
- Discover novel mechanisms regulating self renewal and fate specification of neural stem cells
- Unveil how mutations of genes associated with autism and fragile X syndrome affect brain development
- Mentoring undergraduate and graduate students, postdoctoral fellows, scientists, and junior faculty members